Technical articles

Clean-in-place operations for thin-cake filtration technologies

PharmaChem

This article discusses the choice of thin-cake (2-25 mm) separation technologies and their benefits to optimizing the effectiveness of the production process. The paper continues with a discussion of clean-in-place operations to meet current Good Manufacturing Practices (cGMP) guidelines including riboflavin test and validations. ANSI/ISA S88 (and IEC 61512-1 in the international arena) batch process control system standards are also examined. Finally, factory and site acceptance testing is described.

Published in: PharmaChem - May 2005
PDF (328 KB)
Clean-in-place operations for thin-cake filtration technologies
May 2005
May 2005

Size: 328 KB

What Twin-Shaft Mixing can do for you

Everyone has a general idea what mixing means. But describing this is not so easy. The goal of any mixing process is to distribute materials with different characteristics, and usually in differing quan-tities, as evenly as possible. A new homogeneous material with different properties results.

Published in: The Concrete Producer - October 2004
PDF (1.2 MB)
What Twin-Shaft Mixing can do for you
October 2004
October 2004

Size: 1.2 MB

Vertical Shaft Impactors (VSI) - Crushing Machines for the Production of High-Quality Aggregates

AUFBEREITUNGS TECHNIK

The BHS Rotor Centrifugal Crusher with Two-Chamber Rotor is a further step in the development of VSI crushers which offers the operators excellent crushing results together with attractive operating costs. Detailed operation characteristics are beiing described in the article.

Published in: AUFBEREITUNGS TECHNIK - 45 (2004) Nr. 3
PDF (1.8 MB)
Vertical Shaft Impactors (VSI) - Crushing Machines for the Production of High-Quality Aggregates
45 (2004) Nr. 3
March 2004

Size: 1.8 MB

Process Testing and Scale-UP for a BHS Pharma Rotary Pressure Filter as a Replacement for Two Inverting-Basket Centrifuges at a Bulk Pharmaceutical Manufacturing Facility

BHS-Filtration Inc.

The BHS Ph-RPF technology provides improved product quality with more efficient washing ratios compared with the inverting-basket centrifuges. Savings in solvent usage, energy consumption, maintenance costs and capital and installation costs result in overall project savings on the order of 4-6 to 1.

Published in: BHS-Filtration Inc. - Report Number F-1079-03
PDF (405 KB)
Process Testing and Scale-UP for a BHS Pharma Rotary Pressure Filter as a Replacement for Two Inverting-Basket Centrifuges at a Bulk Pharmaceutical Manufacturing Facility
Report Number F-1079-03
October 2003

Size: 405 KB

Test it Right for Thin-Cake Filtration Operation

Chemical Processing Magazine

The appropriate BHS testing procedures can help direct the selection of pressure or vacuum filtration equipment and ensure optimum equipment operation.

Published in: Chemical Processing Magazine - April 2003
PDF (1.0 MB)
Test it Right for Thin-Cake Filtration Operation
April 2003
April 2003

Size: 1.0 MB

Comparison of Gypsum Dewatering Technologies at Flue Gas Desulfurization Plants

Recovering gypsum from flue gas desulfurization (FGD) plants is becoming more important as the technical feasibility of substituting FGD gypsum for natural gypsum in traditional applications such as wall board, cement and soil conditioners has been demonstrated. It is estimated that there are over 200 new coal-fired plants and over 1000 upgrades of existing coal-fired plants in various stages around the world. An important aspect of gypsum recovery is the solid-liquid separation technology that is used.

Published in: 45th ISA Power Industry Division Conference, San Diego - June 2-7, 2002
PDF (381 KB)
Comparison of Gypsum Dewatering Technologies at Flue Gas Desulfurization Plants
June 2-7, 2002
June 2002

Size: 381 KB

Evaluating thin-cake pressure filtration using the BHS Autopress technology

Chemical Processing Magazine

Thin-cake pressure filtration technology offers an alternative to agitated nutsche filters and centrifuges for solid-liquid separation,cake washing, and drying. Complicating this process is the number of competing technologies and options that can be employed to accomplish these steps. For example, most pharmaceutical processes will use either an agitated nutsche filter or a centrifuge for the separation and washing step. This article discusses the use of the thin-cake Autopress pressure filter as an alternative to agitated nutsche filters and centrifuges. The results are applicable to specialty chemical and other applications with similar process crystals and requirements.

Published in: Chemical Processing Magazine - April 2002
PDF (1.6 MB)
Evaluating thin-cake pressure filtration using the BHS Autopress technology
April 2002
April 2002

Size: 1.6 MB
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