合成药物

可靠地满足所有要求

生产合成药物时针对纯度、最佳滤饼形成和滤液分离提出了最高的要求。我们的过滤系统如 AP 型自动压滤机、BF 型节拍式带式过滤机和 RPF 型加压转鼓过滤机特别适合于此应用领域,并能提供:

  • 间歇式生产或连续生产
  • 压力过滤或真空过滤
  • 小批量或大规模生产
  • 滤饼处理的各种不同可能性
  • 封闭或惰化的过滤机设计型

除了对最终产品的质量要求外,还必须考虑运行的经济性。通过最先进的机械工程技术,我们的系统能满足运行成本低和在工艺技术方面具有竞争力这两个准则。

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宣传册“节拍式带式过滤机 (BF)” (PDF / 1.2 MB)
宣传册“节拍式带式过滤机 (BF)”

作为连续工作的卧式真空过滤机的节拍式带式过滤机(BF)的产品宣传册

大小: 1.2 MB
宣传册“加压转鼓过滤机 (RPF)” (PDF / 1.4 MB)
宣传册“加压转鼓过滤机 (RPF)”

加压转鼓过滤机 (RPF) 的产品宣传册

大小: 1.4 MB

BHS 过滤技术的优点

  • 最高质量的最终产品
  • 符合药品要求的机器设计
  • 滤饼处理的多种可能性
  • 验证符合要求
  • 间歇式或连续运行方式
  • 训练有素的售后服务机构

应用

  • 抗病毒药物
  • 哮喘药物
  • 荷尔蒙衍生物
  • 奥利司他 (Orlistate)
  • 他汀类药物

BHS 过滤技术实验中心

跳转至 BHS 技术实验中心试验的链接

专业技术论文

Thin-cake filtration technology to meet full containment for air-sensitive and toxic chemical and pharmaceutical production

PharmaChem
1/2 2016 (January/February)
二月 2016
PDF (3.5 MB)
Thin-cake filtration technology to meet full containment for air-sensitive and toxic chemical and pharmaceutical production

In many chemical and pharmaceutical processes, solid-liquid separation, cake washing and drying steps directly impact the effectiveness of the production operation. Further complicating these operations is the nature of the process and especially if the process is air-sensitive or toxic. This article discusses the choice of thin-cake (2-25 mm) pressure separation technology for full containment, no residual heel and their benefits to optimizing the effectiveness of the production process. For full containment, the paper then continues with a discussion of clean-in-place operations to meet current Good Manufacturing Practices (cGMP) guidelines including riboflavin test, validations and ANSI/ISA S88 and IEC 61512-1 batch process control systems.

大小: 3.5 MB

A Review of Filter Press Basics Versus Alternative Technologies

PharmaChem
Mai 2008 - 33
五月 2008
PDF (323 KB)
A Review of Filter Press Basics Versus Alternative Technologies

Filtration experts, over the years, have discussed and debated filter presses and have indicated that soon they would be a thing of the past; the last filter press would be replaced by more modern equipment. Given that filter presses were amongst the oldest mechanical dewatering devices, this was a fairly plausible suggestion. However, now, almost half a century later, any chemical engineering exhibition shows that filter presses are alive and well and are going to be around for years to come. True, they look different from the ones in the 1950’s, but essentially they are still the same device. Their continued presence is a tribute to the filter press manufacturers who embraced new materials and upgraded the mechanics and configurations. However, the basics are still the same and much of the issues surrounding filter presses remain valid.

大小: 323 KB

Thin-cake filtration technologies for removing activated carbon, catalysts and other trace solids from Active Pharmaceutical Ingredient (API) slurries

PHARMACEUTICAL ENGINEERING
JANUARY/FEBRUARY 2007
一月 2007
PDF (255 KB)
Thin-cake filtration technologies for removing activated carbon, catalysts and other trace solids from Active Pharmaceutical Ingredient (API) slurries

This article discusses the use of thin-cake vertical candle filters and horizontal pressure plate filters as alternatives to manual and conventional filter equipment. These new technologies are described as well as the selection process. The article includes test data and case histories and concludes with a discussion of clean-in-place operations and current Good Manufacturing Practices (cGMP) guidelines. ANSI/ISA S88 (and IEC 61512-1 in the international arena) batch process control system standards are also examined for validation. Finally, factory and site acceptance testing is described.

大小: 255 KB
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