Synthetic drugs

Assured compliance with all requirements

In the manufacture of synthetic drugs, the strictest requirements must be met with regard to purity, optimum cake formation and filtrate separation. As filter systems, our Autopress (type AP), indexing belt filters (type BF) and rotary pressure filters (type RPF) are especially suitable for these applications and feature:

  • Batch or continuous operation
  • Pressure or vacuum filtration
  • Small-scale or mass production
  • Various options for cake treatment
  • Enclosed or inerted filter designs

Operational efficiency is another key factor in addition to the high quality of the final product. Our systems meet both these criteria thanks to advanced machine technology, low operating costs and our expertise in process engineering.

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Downloads

Brochure "Indexing belt filter (BF)" (PDF / 1.2 MB)
Brochure "Indexing belt filter (BF)"

Product brochure for indexing belt filter (BF) as a continuously operating, horizontal vacuum filter

Size: 1.2 MB
“Rotary pressure filter (RPF)” brochure (PDF / 1.4 MB)
“Rotary pressure filter (RPF)” brochure

Product brochure for the rotary pressure filter (RPF)

Size: 1.4 MB

Advantages of BHS filtration technology

  • Outstanding quality of final products
  • Pharmaceutical-grade machine design
  • Multiple options for cake treatment
  • Compliance with validation requirements
  • Batch or continuous operation
  • Trained service team

Applications

  • Antiviral drugs
  • Asthma drugs
  • Hormone derivatives
  • Orlistat
  • Statins

BHS filtration technical center

Link to tests at BHS technical center

Technical article

Thin-cake filtration technology to meet full containment for air-sensitive and toxic chemical and pharmaceutical production

PharmaChem
1/2 2016 (January/February)
February 2016
PDF (3.5 MB)
Thin-cake filtration technology to meet full containment for air-sensitive and toxic chemical and pharmaceutical production

In many chemical and pharmaceutical processes, solid-liquid separation, cake washing and drying steps directly impact the effectiveness of the production operation. Further complicating these operations is the nature of the process and especially if the process is air-sensitive or toxic. This article discusses the choice of thin-cake (2-25 mm) pressure separation technology for full containment, no residual heel and their benefits to optimizing the effectiveness of the production process. For full containment, the paper then continues with a discussion of clean-in-place operations to meet current Good Manufacturing Practices (cGMP) guidelines including riboflavin test, validations and ANSI/ISA S88 and IEC 61512-1 batch process control systems.

Size: 3.5 MB

A Review of Filter Press Basics Versus Alternative Technologies

PharmaChem
Mai 2008 - 33
May 2008
PDF (323 KB)
A Review of Filter Press Basics Versus Alternative Technologies

Filtration experts, over the years, have discussed and debated filter presses and have indicated that soon they would be a thing of the past; the last filter press would be replaced by more modern equipment. Given that filter presses were amongst the oldest mechanical dewatering devices, this was a fairly plausible suggestion. However, now, almost half a century later, any chemical engineering exhibition shows that filter presses are alive and well and are going to be around for years to come. True, they look different from the ones in the 1950’s, but essentially they are still the same device. Their continued presence is a tribute to the filter press manufacturers who embraced new materials and upgraded the mechanics and configurations. However, the basics are still the same and much of the issues surrounding filter presses remain valid.

Size: 323 KB

Thin-cake filtration technologies for removing activated carbon, catalysts and other trace solids from Active Pharmaceutical Ingredient (API) slurries

PHARMACEUTICAL ENGINEERING
JANUARY/FEBRUARY 2007
January 2007
PDF (255 KB)
Thin-cake filtration technologies for removing activated carbon, catalysts and other trace solids from Active Pharmaceutical Ingredient (API) slurries

This article discusses the use of thin-cake vertical candle filters and horizontal pressure plate filters as alternatives to manual and conventional filter equipment. These new technologies are described as well as the selection process. The article includes test data and case histories and concludes with a discussion of clean-in-place operations and current Good Manufacturing Practices (cGMP) guidelines. ANSI/ISA S88 (and IEC 61512-1 in the international arena) batch process control system standards are also examined for validation. Finally, factory and site acceptance testing is described.

Size: 255 KB
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